Cover image

Nanotheranostics, the sister journal of Theranostics, is a multidisciplinary and fully open access journal. Nanotheranostics publishes innovative and original basic, translational and clinical research reflecting the fields of nanomedicine, nanoimaging, drug and gene delivery, nanoelectronic biosensors, and other areas. 

Regular features include high quality research articles, reviews or mini-reviews, rapid communication of preliminary data on innovative research, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical studies or ethical issues of nanomedicine are also welcome. Timely reviews that provide updates on current applications and issues in nanomedicine and translational aspects of nanotheranostics and other topics are particularly welcome and will be given high priority.

Nanotheranostics employs a rigorous peer-review system, but also strives for rapid review turnaround times and is based on the same streamlined submission platform as Theranostics.

Recent Papers:


toc.jpg

Research Paper
A Scalable Method for Squalenoylation and Assembly of Multifunctional 64Cu-Labeled Squalenoylated Gemcitabine Nanoparticles
Samantha T. Tucci, Jai W. Seo, Hamilton Kakwere, Azadeh Kheirolomoom, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Spencer Tumbale, Mo Baikoghli, Holland Cheng, Katherine W. Ferrara
Nanotheranostics 2018; 2(4): 387-402. doi:10.7150/ntno.26969
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy
Feng Yin, Tommy Anderson, Nishtha Panwar, Kang Zhang, Swee Chuan Tjin, Beng Koon Ng, Ho Sup Yoon, Junle Qu, Ken-Tye Yong
Nanotheranostics 2018; 2(4): 371-386. doi:10.7150/ntno.27308
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer
Yongmei Zhao, Nicholas L. Fletcher, Tianqing Liu, Anna C. Gemmell, Zachary H. Houston, Idriss Blakey, Kristofer J. Thurecht
Nanotheranostics 2018; 2(4): 360-370. doi:10.7150/ntno.27142
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage
Shuxin Li, Wei Cong, Amirhossein Hakamivala, YiHui Huang, Joseph Borrelli, Liping Tang
Nanotheranostics 2018; 2(4): 347-359. doi:10.7150/ntno.26119
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?
Valeriy M Paramonov, Diti Desai, Helene Kettiger, Veronika Mamaeva, Jessica M Rosenholm, Cecilia Sahlgren, Adolfo Rivero-Müller
Nanotheranostics 2018; 2(4): 320-346. doi:10.7150/ntno.23826
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection
Kai Li, Carmel T. Chan, Hossein Nejadnik, Olga D. Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E. Daldrup-Link
Nanotheranostics 2018; 2(4): 306-319. doi:10.7150/ntno.26389
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
Shellie S. Knights-Mitchell, Marek Romanowski
Nanotheranostics 2018; 2(4): 295-305. doi:10.7150/ntno.22544
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
HAase-sensitive dual-targeting irinotecan liposomes enhance the therapeutic efficacy of lung cancer in animals
Liang Zhang, Haixin Cui
Nanotheranostics 2018; 2(3): 280-294. doi:10.7150/ntno.25555
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Genome-wide Transcriptional Analysis of Oxidative Stress-related Genes and Pathways Induced by CdTe aqQDs in Mice
Ling Kong, Jiayi Li, Jilong Wang, Yue Hu, Peijun Meng, Yamin Xiong, Peili Huang
Nanotheranostics 2018; 2(3): 271-279. doi:10.7150/ntno.24590
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Editorial
Passing the Baton - From the Editor-in-Chief
Moritz F. Kircher
Nanotheranostics 2018; 2(3): 269-270. doi:10.7150/ntno.27567
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Clinically-Applicable Perfluorocarbon-Loaded Nanoparticles For In vivo Photoacoustic, 19F Magnetic Resonance And Fluorescent Imaging
Edyta Swider, Khalid Daoudi, Alexander H. J. Staal, Olga Koshkina, N. Koen van Riessen, Eric van Dinther, I. Jolanda M. de Vries, Chris L. de Korte, Mangala Srinivas
Nanotheranostics 2018; 2(3): 258-268. doi:10.7150/ntno.26208
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Nd3+ sensitized core-shell-shell nanocomposites loaded with IR806 dye for photothermal therapy and up-conversion luminescence imaging by a single wavelength NIR light irradiation
Syue-Liang Lin, Zi-Rong Chen, C. Allen Chang
Nanotheranostics 2018; 2(3): 243-257. doi:10.7150/ntno.25901
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Multifunctional Magnetic Mesoporous Silica Nanoagents for in vivo Enzyme-Responsive Drug Delivery and MR Imaging
Erdong Li, Yanmei Yang, Guangyu Hao, Xuan Yi, Shaohua Zhang, Yue Pan, Bengang Xing, Mingyuan Gao
Nanotheranostics 2018; 2(3): 233-242. doi:10.7150/ntno.25565
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Bio-transformation of Graphene Oxide in Lung Fluids Significantly Enhances Its Photothermal Efficacy
Yun Liu, Yu Qi, Chunyang Yin, Shunhao Wang, Shuping Zhang, An Xu, Wei Chen, Sijin Liu
Nanotheranostics 2018; 2(3): 222-232. doi:10.7150/ntno.25719
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles
Shuyao Li, Shuwei Liu, Lu Wang, Min Lin, Rui Ge, Xing Li, Xue Zhang, Yi Liu, Lening Zhang, Hongchen Sun, Hao Zhang, Bai Yang
Nanotheranostics 2018; 2(3): 211-221. doi:10.7150/ntno.25119
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Non-invasive Early Response Monitoring of Nanoparticle-assisted Photothermal Cancer Therapy Using 18F-FDG, 18F-FLT, and 18F-FET PET/CT Imaging
Jesper Tranekjær Jørgensen, Kamilla Norregaard, Marina Simón Martín, Lene Broeng Oddershede, Andreas Kjaer
Nanotheranostics 2018; 2(3): 201-210. doi:10.7150/ntno.24478
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Editors-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*

Moritz Kircher, MD, PhD, Memorial Sloan Kettering Cancer Center
Editors-in-chief profile
* Dr. Chen is serving in his personal capacity.

new Nanotheranostics in PubMed Central

Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbersome, time-consuming and can be difficult to reliably replicate. Further, the creation of multi-functional SqGem-based NP theranostics would facilitate characterization of in vivo pharmacokinetics and efficacy. More ...
Anticancer nanotherapeutics have shown mixed results in clinical trials, raising the questions of whether imaging should be used to i) identify patients with a higher likelihood of nanoparticle accumulation, ii) assess nanotherapeutic efficacy before traditional measures show response, and iii) guide adjuvant treatments to enhance therapeutic nanoparticle (TNP) delivery. Here we review the use of a clinically approved MRI nanoparticle (ferumoxytol, FMX) to predict TNP delivery and efficacy. It is becoming increasingly apparent that nanoparticles used for imaging, despite clearly distinct physicochemical properties, often co-localize with TNP in tumors. This evidence offers the possibility of using FMX as a generic “companion diagnostic” nanoparticle for multiple TNP formulations, thus potentially allowing many of the complex regulatory and cost challenges of other approaches to be avoided. More ...
Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/
Theme Issue on “Virus-inspired Nanomedicine”. Guest Editor: Chuanbin Mao, PhD.
Theme Issue on “Nanotechnology for high precision cancer detection, delineation, and destruction”. Guest Editor: Dr. Moritz Kircher.
Theme Issue on “Biopolymer-based nanomaterials for theranostic applications”. Guest Editor: Dr. Won Jong Kim.
Theme Issue on “Nanoscale Platforms for In Vitro Diagnostics”. Guest Editor: Dr. Dingbin Liu.
Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/