Cover image

Nanotheranostics, the sister journal of Theranostics, is a multidisciplinary and fully open access journal. Nanotheranostics publishes innovative and original basic, translational and clinical research reflecting the fields of nanomedicine, nanoimaging, drug and gene delivery, nanoelectronic biosensors, and other areas. 

Regular features include high quality research articles, reviews or mini-reviews, rapid communication of preliminary data on innovative research, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical studies or ethical issues of nanomedicine are also welcome. Timely reviews that provide updates on current applications and issues in nanomedicine and translational aspects of nanotheranostics and other topics are particularly welcome and will be given high priority.

Nanotheranostics employs a rigorous peer-review system, but also strives for rapid review turnaround times and is based on the same streamlined submission platform as Theranostics.

Recent Papers:


toc.jpg

Research Paper
Nanomedicine-Assisted Combination Therapy of NSCLC: New Platinum-Based Anticancer Drug Synergizes the Therapeutic Efficacy of Ganetespib
Jyothi Kallu, Tuhina Banerjee, Shoukath Sulthana, Saloni Darji, Ryan Higginbotham, Christina Fletcher, Nikolay N. Gerasimchuk, Santimukul Santra
Nanotheranostics 2019; 3(1): 120-134. doi:10.7150/ntno.28468
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Alkyne- and Nitrile-Anchored Gold Nanoparticles for Multiplex SERS Imaging of Biomarkers in Cancer Cells and Tissues
Mingmin Li, Jianzhen Wu, Mengtian Ma, Zhichao Feng, Ze Mi, Pengfei Rong, Dingbin Liu
Nanotheranostics 2019; 3(1): 113-119. doi:10.7150/ntno.30924
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
Einar Sulheim, Yrr Mørch, Sofie Snipstad, Sven Even Borgos, Hrvoje Miletic, Rolf Bjerkvig, Catharina de Lange Davies, Andreas K.O. Åslund
Nanotheranostics 2019; 3(1): 103-112. doi:10.7150/ntno.31479
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment
Mohan Singh, Elham Nabavi, Yu Zhou, Maria Elena Gallina, Hailin Zhao, Pakatip Ruenraroengsak, Alexandra E. Porter, Daqing Ma, Anthony E. G. Cass, George B. Hanna, Daniel S. Elson
Nanotheranostics 2019; 3(1): 89-102. doi:10.7150/ntno.28585
[Abstract] [Full text] [PDF]


toc.jpg

Review
Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment
Derek Reichel, Manisha Tripathi, J. Manuel Perez
Nanotheranostics 2019; 3(1): 66-88. doi:10.7150/ntno.30052
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Comparing Semiconductor Nanocrystal Toxicity in Pregnant Mice and Non-Human Primates
Ling Ye, Rui Hu, Liwei Liu, Jianwei Liu, Jing Liu, Hongyan Chen, Yazhuo Hu, Yaqian Liu, Xin Liu, Cui Liu, Danny Jian Hang Tng, Yuanguang Meng, Junle Qu, Mark T. Swihart, Ken-Tye Yong
Nanotheranostics 2019; 3(1): 54-65. doi:10.7150/ntno.27452
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer
Liqun Huang, Chang Xu, Peng Xu, Yu Qin, Mengwei Chen, Qishuai Feng, Jing Pan, Qian Cheng, Feng Liang, Xiaofei Wen, Ying Wang, Yufang Shi, Yu Cheng
Nanotheranostics 2019; 3(1): 41-53. doi:10.7150/ntno.28450
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Review
Theragnostic potentials of core/shell mesoporous silica nanostructures
Aswathy Ravindran Girija, Sivakumar Balasubramanian
Nanotheranostics 2019; 3(1): 1-40. doi:10.7150/ntno.27877
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
MnO2-gated Nanoplatforms with Targeted Controlled Drug Release and Contrast-Enhanced MRI Properties: from 2D Cell Culture to 3D Biomimetic Hydrogels
Yupeng Shi, Flavien Guenneau, Xiaolin Wang, Christophe Hélary, Thibaud Coradin
Nanotheranostics 2018; 2(4): 403-416. doi:10.7150/ntno.28046
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
A Scalable Method for Squalenoylation and Assembly of Multifunctional 64Cu-Labeled Squalenoylated Gemcitabine Nanoparticles
Samantha T. Tucci, Jai W. Seo, Hamilton Kakwere, Azadeh Kheirolomoom, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Spencer Tumbale, Mo Baikoghli, Holland Cheng, Katherine W. Ferrara
Nanotheranostics 2018; 2(4): 387-402. doi:10.7150/ntno.26969
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy
Feng Yin, Tommy Anderson, Nishtha Panwar, Kang Zhang, Swee Chuan Tjin, Beng Koon Ng, Ho Sup Yoon, Junle Qu, Ken-Tye Yong
Nanotheranostics 2018; 2(4): 371-386. doi:10.7150/ntno.27308
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer
Yongmei Zhao, Nicholas L. Fletcher, Tianqing Liu, Anna C. Gemmell, Zachary H. Houston, Idriss Blakey, Kristofer J. Thurecht
Nanotheranostics 2018; 2(4): 360-370. doi:10.7150/ntno.27142
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage
Shuxin Li, Wei Cong, Amirhossein Hakamivala, YiHui Huang, Joseph Borrelli, Liping Tang
Nanotheranostics 2018; 2(4): 347-359. doi:10.7150/ntno.26119
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?
Valeriy M Paramonov, Diti Desai, Helene Kettiger, Veronika Mamaeva, Jessica M Rosenholm, Cecilia Sahlgren, Adolfo Rivero-Müller
Nanotheranostics 2018; 2(4): 320-346. doi:10.7150/ntno.23826
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection
Kai Li, Carmel T. Chan, Hossein Nejadnik, Olga D. Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E. Daldrup-Link
Nanotheranostics 2018; 2(4): 306-319. doi:10.7150/ntno.26389
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
Shellie S. Knights-Mitchell, Marek Romanowski
Nanotheranostics 2018; 2(4): 295-305. doi:10.7150/ntno.22544
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Editor-in-Chief:
Moritz F. Kircher, MD, PhD
Chair, Department of Imaging and Radiology
Dana-Farber Cancer Institute &
Harvard Medical School
Editor-in-chief profile

new Congratulations to Dr. Moritz F. Kircher who has been appointed Chair of the Department of Imaging and Radiology, Dana-Farber Cancer Institute, Harvard Medical School!

new In its latest meeting, the Literature Selection Technical Review Committee (LSTRC) has selected Nanotheranostics for inclusion in MEDLINE, the prestigious index of U.S. National Library of Medicine. Congratulations!

Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbersome, time-consuming and can be difficult to reliably replicate. Further, the creation of multi-functional SqGem-based NP theranostics would facilitate characterization of in vivo pharmacokinetics and efficacy. More ...
Anticancer nanotherapeutics have shown mixed results in clinical trials, raising the questions of whether imaging should be used to i) identify patients with a higher likelihood of nanoparticle accumulation, ii) assess nanotherapeutic efficacy before traditional measures show response, and iii) guide adjuvant treatments to enhance therapeutic nanoparticle (TNP) delivery. Here we review the use of a clinically approved MRI nanoparticle (ferumoxytol, FMX) to predict TNP delivery and efficacy. It is becoming increasingly apparent that nanoparticles used for imaging, despite clearly distinct physicochemical properties, often co-localize with TNP in tumors. This evidence offers the possibility of using FMX as a generic “companion diagnostic” nanoparticle for multiple TNP formulations, thus potentially allowing many of the complex regulatory and cost challenges of other approaches to be avoided. More ...
Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/
Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/