Nanotheranostics 2017; 1(2):186-195. doi:10.7150/ntno.18619

Research Paper

Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging

Hongguang Li1, Bethany I. Harriss2, Alkystis Phinikaridou3, Sara Lacerda3, Gregory Ramniceanu5, 6, Bich-Thuy Doan5, 6, Ka-Lok Ho1, Chi-Fai Chan1, 4, Wai-Sum Lo4, René M. Botnar3, Rongfeng Lan1, Cyrille Richard5, 6✉, Ga-Lai Law4✉, Nicholas J. Long2✉, Ka-Leung Wong1✉

1. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR;
2. Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK;
3. King's College London, Division of Imaging Sciences, Lambeth Wing, St Thomas' Hospital London SE1 7EH;
4. Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR;
5. Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS); CNRS UMR 8258; Inserm U 1022; Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France;
6. Chimie-ParisTech, PSL, 75005 Paris, France.

Abstract

A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM-1s-1 at 3T, 25 oC) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.

Keywords: prodrug, multi-modal, MRI, drug delivery, fluorescence imaging, cisplatin.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Li H, Harriss BI, Phinikaridou A, Lacerda S, Ramniceanu G, Doan BT, Ho KL, Chan CF, Lo WS, Botnar RM, Lan R, Richard C, Law GL, Long NJ, Wong KL. Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging. Nanotheranostics 2017; 1(2):186-195. doi:10.7150/ntno.18619. Available from http://www.ntno.org/v01p0186.htm