Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment

Barbezan, Angélica Bueno; Rosero, Wilmmer Alexander Arcos; Vieira, Daniel Perez; Rigo, Maria Eduarda Zaganin; da Silva, Giovana Dias; Rodrigues, Alex Alves; de Almeida, Luís Fernando; da Silva, Fábio Fernando Alves; Rivera, Andy González; da Silva, Natanael Gomes; Bernardes, Emerson S.; Zeituni, Carlos Alberto; Rostelato, Maria Elisa C. M.

doi:10.7150/ntno.91507

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Theranostics

International Journal of Biological Sciences

International Journal of Medical Sciences

Journal of Cancer

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Nanotheranostics 2024; 8(1):112-126. doi:10.7150/ntno.91507 This issue Cite

Research Paper

Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment

Angélica Bueno Barbezan^1✉, Wilmmer Alexander Arcos Rosero¹, Daniel Perez Vieira³, Maria Eduarda Zaganin Rigo¹, Giovana Dias da Silva³, Alex Alves Rodrigues³, Luís Fernando de Almeida¹, Fábio Fernando Alves da Silva², Andy González Rivera², Natanael Gomes da Silva², Emerson S. Bernardes², Carlos Alberto Zeituni¹, Maria Elisa C. M. Rostelato¹

1. IPEN /CETER (Instituto de Pesquisas Energéticas e Nucleares / Centro de Tecnologia das Radiações), Brazil.
2. IPEN /CECRF (Instituto de Pesquisas Energéticas e Nucleares / Centro de Radiofármacia), Brazil.
3. IPEN / CBIO (Instituto de Pesquisas Energéticas e Nucleares / Centro de Biotecnologia), Brazil.

Citation:

Barbezan AB, Rosero WAA, Vieira DP, Rigo MEZ, da Silva GD, Rodrigues AA, de Almeida LF, da Silva FFA, Rivera AG, da Silva NG, Bernardes ES, Zeituni CA, Rostelato MECM. Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment. Nanotheranostics 2024; 8(1):112-126. doi:10.7150/ntno.91507. https://www.ntno.org/v08p0112.htm

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Abstract

Background: Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches.

Methods: AuNPs coated with bovine serum albumin (BSA) were synthesized and their cytotoxicity was assessed against prostate tumor cell lines (LNCaP and PC-3), healthy prostate cells (RWPE-1), and endothelial control cells (HUVEC) using the MTS/PMS assay. For in vivo studies, BALB/C Nude mice were employed to gauge the therapeutic efficacy, biodistribution, and hematological implications post-treatment with BSA-coated AuNPs.

Results: The BSA-coated AuNPs exhibited cytotoxic potential against PC-3 and LNCaP lines, while interactions with RWPE-1 and HUVEC remain subjects for further scrutiny. Within animal models, a diverse therapeutic response was observed, with certain instances indicating complete tumor regression. Biodistribution data emphasized the nanoparticles' affinity towards particular organs, and the majority of hematological indicators aligned with normative standards.

Conclusions: BSA-coated AuNPs manifest substantial promise as therapeutic tools in treating prostate cancer. The present research not only accentuates the nanoparticles' efficacy but also stresses the imperative of optimization to ascertain both selectivity and safety. Such findings illuminate a promising trajectory for avant-garde therapeutic modalities, holding substantial implications for public health advancements.

Keywords: Radioactive Gold Nanoparticles (AuNPs), Nanobrachytherapy, Prostate Cancer, Cytotoxicity, Therapeutic Efficacy

Citation styles

APA

Barbezan, A.B., Rosero, W.A.A., Vieira, D.P., Rigo, M.E.Z., da Silva, G.D., Rodrigues, A.A., de Almeida, L.F., da Silva, F.F.A., Rivera, A.G., da Silva, N.G., Bernardes, E.S., Zeituni, C.A., Rostelato, M.E.C.M. (2024). Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment. Nanotheranostics, 8(1), 112-126. https://doi.org/10.7150/ntno.91507.

ACS

Barbezan, A.B.; Rosero, W.A.A.; Vieira, D.P.; Rigo, M.E.Z.; da Silva, G.D.; Rodrigues, A.A.; de Almeida, L.F.; da Silva, F.F.A.; Rivera, A.G.; da Silva, N.G.; Bernardes, E.S.; Zeituni, C.A.; Rostelato, M.E.C.M. Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment. Nanotheranostics 2024, 8 (1), 112-126. DOI: 10.7150/ntno.91507.

NLM

CSE

Barbezan AB, Rosero WAA, Vieira DP, Rigo MEZ, da Silva GD, Rodrigues AA, de Almeida LF, da Silva FFA, Rivera AG, da Silva NG, Bernardes ES, Zeituni CA, Rostelato MECM. 2024. Radioactive gold nanoparticles coated with BSA: A promising approach for prostate cancer treatment. Nanotheranostics. 8(1):112-126.

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