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Nanotheranostics, the sister journal of Theranostics, is a multidisciplinary and fully open access journal. Currently, the journal does not charge any publication or submission fees (Platinum open access). Nanotheranostics publishes innovative and original basic, translational and clinical research reflecting the fields of nanomedicine, nanoimaging, drug and gene delivery, nanoelectronic biosensors, and other areas. 

Regular features include high quality research articles, reviews or mini-reviews, rapid communication of preliminary data on innovative research, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical studies or ethical issues of nanomedicine are also welcome. Timely reviews that provide updates on current applications and issues in nanomedicine and translational aspects of nanotheranostics and other topics are particularly welcome and will be given high priority.

Nanotheranostics employs a rigorous peer-review system, but also strives for rapid review turnaround times and is based on the same streamlined submission platform as Theranostics.

Recent Papers:


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Research Paper
Flavin Adenine Dinucleotide (FAD) Pegylated (PEG)-Complexes: Proof of Concept (PoC) of theranostic tool on a Murine Breast Cancer Model
Celia Arib, Hui Liu, Qiqian Liu, Anne-Marie Cieutat, Didier Paleni, Xiaowu Li, Jolanda Spadavecchia
Nanotheranostics 2022; 6(2): 175-183. doi:10.7150/ntno.63496
[Abstract] [Full text] [PDF]


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Research Paper
Development of CD44E/s dual-targeting DNA aptamer as nanoprobe to deliver treatment in hepatocellular carcinoma
Cario Wing-Sze Lo, Cecilia Ka Wing Chan, Jianqing Yu, Mian He, Chung Hang Jonathan Choi, James Yun Wong Lau, Nathalie Wong
Nanotheranostics 2022; 6(2): 161-174. doi:10.7150/ntno.62639
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Research Paper
Metal-Organic Frameworks for Bioimaging: Strategies and Challenges
Yanfei Liu, Ting Jiang, Zhenbao Liu
Nanotheranostics 2022; 6(2): 143-160. doi:10.7150/ntno.63458
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Research Paper
Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
Kristen R. Hollinger, Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu, Robyn Wiseman, Ying Wu, Siva P. Kambhampati, Kevin Liaw, Rishi Sharma, Camilo Rojas, Rana Rais, Sujatha Kannan, Rangaramanujam M. Kannan, Barbara S. Slusher
Nanotheranostics 2022; 6(2): 126-142. doi:10.7150/ntno.63158
[Abstract] [Full text] [PDF]


Editorial
Special Issue Dedicated to Dr. Gambhir and Dr. Kircher
Jonathan F Lovell
Nanotheranostics 2022; 6(1): 125. doi:10.7150/ntno.68107
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In Memory
A personal tribute to Sanjiv Sam Gambhir MD PHD
Natesh Parashurama
Nanotheranostics 2022; 6(1): 123-124. doi:10.7150/ntno.67358
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In Memory
The brightest stars - a tribute to Moritz Kircher
Chrysafis Andreou
Nanotheranostics 2022; 6(1): 121-122. doi:10.7150/ntno.63531
[Abstract] [Full text] [PDF]


In Memory
In memory of Michael R. Detty, PhD
David Watson, Stefan Harmsen
Nanotheranostics 2022; 6(1): 118-120. doi:10.7150/ntno.63716
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Review
Radiotheranostics - Precision Medicine in Nuclear Medicine and Molecular Imaging
Heying Duan, Andrei Iagaru, Carina Mari Aparici
Nanotheranostics 2022; 6(1): 103-117. doi:10.7150/ntno.64141
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Review
Near-infrared probes for luminescence lifetime imaging
Benhao Li, Jing Lin, Peng Huang, Xiaoyuan Chen
Nanotheranostics 2022; 6(1): 91-102. doi:10.7150/ntno.63124
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Research Paper
Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window
Wonjun Yim, Raina M. Borum, Jiajing Zhou, Yash Mantri, Zhuohong Wu, Jingcheng Zhou, Zhicheng Jin, Matthew Creyer, Jesse V. Jokerst
Nanotheranostics 2022; 6(1): 79-90. doi:10.7150/ntno.63634
[Abstract] [Full text] [PDF]


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Research Paper
Ultrasound-Guided Microbubble-Mediated Locoregional Delivery of Multiple MicroRNAs Improves Chemotherapy in Hepatocellular Carcinoma
Huaijun Wang, Zhongqian Hu, Uday Kumar Sukumar, Rajendran JC Bose, Arsenii Telichko, Jeremy J Dahl, Ramasamy Paulmurugan
Nanotheranostics 2022; 6(1): 62-78. doi:10.7150/ntno.63320
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Review
Review on Optical Imaging Techniques for Multispectral Analysis of Nanomaterials
Haeni Lee, Jaeheung Kim, Hyung-Hoi Kim, Chang-Seok Kim, Jeesu Kim
Nanotheranostics 2022; 6(1): 50-61. doi:10.7150/ntno.63222
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Review
Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology
Kenry, Fay Nicolson, Louise Clark, Sajanlal R. Panikkanvalappil, Bohdan Andreiuk, Chrysafis Andreou
Nanotheranostics 2022; 6(1): 31-49. doi:10.7150/ntno.62970
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Review
Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications
Bohdan Andreiuk, Fay Nicolson, Louise M. Clark, Sajanlal R. Panikkanvalappil, Kenry, Mohammad Rashidian, Stefan Harmsen, Moritz F. Kircher
Nanotheranostics 2022; 6(1): 10-30. doi:10.7150/ntno.61244
[Abstract] [Full text] [PDF]


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Research Paper
Design and evaluation of Raman reporters for the Raman-silent region
Konstantinos Plakas, Lauren E. Rosch, Michael D. Clark, Shukree Adbul-Rashed, Travis M. Shaffer, Stefan Harmsen, Sanjiv S. Gambhir, Michael R. Detty
Nanotheranostics 2022; 6(1): 1-9. doi:10.7150/ntno.58965
[Abstract] [Full text] [PDF]

More ...

Editor-in-Chief:
Jonathan Lovell, PhD
Associate Professor, Biomedical Engineering
University at Buffalo, State University of New York
new Nanotheranostics is now indexed in the Web of Science, Biological Abstracts and BIOSIS Previews.

Nanotheranostics has been selected by The Literature Selection Technical Review Committee (LSTRC) for inclusion in MEDLINE, the prestigious index of U.S. National Library of Medicine.

Gold nanorods (GNRs) have attracted great interest for photo-mediated biomedicines due to their tunable and high optical absorption, high photothermal conversion efficiency and facile surface modifiability. GNRs that have efficient absorption in second near-infrared (NIR-II) window hold further promise in bio-applications due to low background signal from tissue and deep tissue penetration. However, bare GNRs readily undergo shape deformation (termed as 'melting effect') during the laser illumination losing their unique localized surface plasmon resonance (LSPR) properties, which subsequently leads....
'See what you treat and treat what you see, at a molecular level', could be the motto of theranostics. The concept implies diagnosis (imaging) and treatment of cells (usually cancer) using the same molecule, thus guaranteeing a targeted cytotoxic approach of the imaged tumor cells while sparing healthy tissues. As the brilliant late Sam Gambhir would say, the imaging agent acts like a 'molecular spy' and reveals where the tumoral cells are located and the extent of disease burden (diagnosis). For treatment, the same 'molecular spy' docks to the same tumor cells, this time delivering cytotoxic doses....
Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no treatments. Reduced brain N-acetylaspartylglutamate (NAAG) levels are linked to impaired cognition in various neurological diseases, including MS. NAAG levels are regulated by glutamate carboxypeptidase II (GCPII), which hydrolyzes the neuropeptide to N-acetyl-aspartate and glutamate. GCPII activity is upregulated multifold in microglia following neuroinflammation. Although several GCPII inhibitors, such as 2-PMPA, elevate brain NAAG levels and restore cognitive function in preclinical studies when given at....
Rationale: To assess treatment effects of 4 complementary miRNAs (miRNA-100/miRNA-122/antimiRNA-10b/antimiRNA-21) encapsulated in a biodegradable PLGA-PEG nanoparticle, administered by an ultrasound-guided microbubble-mediated targeted delivery (UGMMTD) approach in mouse models of hepatocellular carcinoma (HCC). Methods: In vitro apoptotic index was measured in HepG2 and Hepa1-6 HCC cells treated with various combinations of the 4 miRNAs with doxorubicin. Three promising combinations were further tested in vivo by using UGMMTD. 63 HepG2 xenografts in mice were randomized into: group 1, miRNA-122/antimiRNA-10b/antimiRNA-21/US/doxorubicin;....
Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/