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Nanotheranostics 2017; 1(3):313-325. doi:10.7150/ntno.20468 This issue Cite

Research Paper

Substitution of Percutaneous Ethanol Injection with a Low Molecular Weight Peptide Gel Mimicking Chemoembolization for Cancer Therapy

Long Xu^1*, Yan Liang^1*, Changzheng Sun¹, Na Hao¹, Jianqin Yan¹, Wenxia Gao^2✉, Bin He^1✉

1. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;
2. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
* These authors contributed equally to this work.

✉ Corresponding authors: wenxiagedu.cn (W. Gao); bheedu.cn (B. He)

Abstract

In order to avoid the instability and quick separation between emulsifier and drug in the interventional chemoembolization, an injectable low molecular weight peptide gel (LMWG) was prepared to localize ethanol and chemotherapeutic for in situ synergistic therapy. The formation mechanism, rheological property and morphology of the LMWG were investigated by NMR, UV-vis, MS and SEM. The interaction between gelator and anticancer drug doxorubicin hydrochloride (DOX) was evaluated by fluorescence spectroscopy and its contribution on drug loading properties was demonstrated. The gel was non-toxic to both 3T3 fibroblasts and 4T1 breast cancer cells. DOX as well as ethanol were encapsulated in the gel and injected in breast cancer bearing mice with low drug dose (2.5 mg/kg body weight). The LMWG surrounded tumors act as a depot for ethanol release and release DOX to induce the apoptosis of cancer cells. With the combination of percutaneous ethanol injection (PEI) and chemotherapy, the DOX loaded LMWG exhibited great significance in necrosis of tumor tissue and exciting tumor inhibition efficiency.

Keywords: low molecular weight peptide gel, drug delivery, chemoembolization, percutaneous ethanol injection, in situ chemotherapy.

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