Nanotheranostics 2018; 2(1):59-69. doi:10.7150/ntno.22754 This issue Cite

Research Paper

Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy

Le Liu, Zheng Ruan, Pan Yuan, Tuanwei Li, Lifeng Yan

CAS Key Laboratory of Soft Matter Chemistry, Department of Chemical Physics, iCHEM, University of Science and Technology of China. Hefei, 230036, P.R. China.

Citation:
Liu L, Ruan Z, Yuan P, Li T, Yan L. Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy. Nanotheranostics 2018; 2(1):59-69. doi:10.7150/ntno.22754. https://www.ntno.org/v02p0059.htm
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Abstract

Graphic abstract

Near infrared (NIR) imaging-guided photodynamic therapy (PDT) is remarkable for its high-efficiency in “see and treat” field. However, hypoxia of cancer cell limits PDT dues to the low singlet oxygen yield. Here MnO2 conjugated multifunctional polypeptide nanoparticles encapsulating photosensitizer BODIPY has been prepared via a one-step reaction, which can generate oxygen in cancer cytoplasm where rich of H2O2, following singlet oxygen by photosensitizer under NIR light irradiation. In vitro studies on HepG2 and 4T1 cancer cells revealed that the as-prepared nanoparticles obviously increase the cell suppression rate under hypoxia conditions, even exposed to an extremely low light energy density (25 mW/cm2). Meanwhile, excellent NIR fluorescence property of BODIPY enabled the nanoparticles to light up the cancer cells for real-time imaging. These results suggest the promises of biocompatible and biodegradable nanoparticles has potential application on efficient NIR imaging-guided photodynamic therapy.

Keywords: polypeptide nanoparticles, photodynamic therapy (PDT), near-infrared fluorescence (NIRF), imaging-guided, hypoxia


Citation styles

APA
Liu, L., Ruan, Z., Yuan, P., Li, T., Yan, L. (2018). Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy. Nanotheranostics, 2(1), 59-69. https://doi.org/10.7150/ntno.22754.

ACS
Liu, L.; Ruan, Z.; Yuan, P.; Li, T.; Yan, L. Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy. Nanotheranostics 2018, 2 (1), 59-69. DOI: 10.7150/ntno.22754.

NLM
Liu L, Ruan Z, Yuan P, Li T, Yan L. Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy. Nanotheranostics 2018; 2(1):59-69. doi:10.7150/ntno.22754. https://www.ntno.org/v02p0059.htm

CSE
Liu L, Ruan Z, Yuan P, Li T, Yan L. 2018. Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy. Nanotheranostics. 2(1):59-69.

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