Cell membrane coated smart two-dimensional supraparticle for <i>in vivo</i> homotypic cancer targeting and enhanced combinational theranostics

Zhang, Di; Ye, Zhongju; Liu, Hua; Wang, Xin; Hua, Jianhao; Ling, Yunyun; Wei, Lin; Xia, Yunsheng; Sun, Shaokai; Xiao, Lehui

doi:10.7150/ntno.57657

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Nanotheranostics 2021; 5(3):275-287. doi:10.7150/ntno.57657 This issue Cite

Research Paper

Cell membrane coated smart two-dimensional supraparticle for in vivo homotypic cancer targeting and enhanced combinational theranostics

Di Zhang^1,2*, Zhongju Ye^1,2*, Hua Liu², Xin Wang², Jianhao Hua², Yunyun Ling³, Lin Wei⁴, Yunsheng Xia^3✉, Shaokai Sun^5✉, Lehui Xiao^2✉

1. College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
2. State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, China.
3. Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, China.
4. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
5. School of Medical Imaging, Tianjin Medical University, Tianjin, 300071, China.
* These authors contributed equally to this work.

Citation:

Zhang D, Ye Z, Liu H, Wang X, Hua J, Ling Y, Wei L, Xia Y, Sun S, Xiao L. Cell membrane coated smart two-dimensional supraparticle for in vivo homotypic cancer targeting and enhanced combinational theranostics. Nanotheranostics 2021; 5(3):275-287. doi:10.7150/ntno.57657. https://www.ntno.org/v05p0275.htm

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Abstract

Development of intelligent and multifunctional nanoparticle for the diagnosis and treatment of cancer has drawn great attention recently. In this work, we design a smart two-dimensional (2D) supraparticle for tumor targeted magnetic resonance imaging (MRI)/photothermal imaging (PTI) and chemo/photothermal therapy (PTT).

Methods: The nanoparticle consists of a manganese dioxide (MnO₂) nanosheet coated gold nanorod (GNR) core (loading with chemotherapeutics doxorubicin (DOX)), and cancer cell membrane shell (denoted as CM-DOX-GMNPs). Decoration of cell membrane endows the nanoparticle with greatly improved colloidal stability and homotypic cancer cell targeting ability. Once the nanoparticles enter tumor cells, MnO₂ nanosheets can be etched to Mn²⁺ by glutathione (GSH) and acidic hydrogen peroxide (H₂O₂) in the cytosol, leading to the release of DOX. Meanwhile, stimuli dependent releasing of Mn²⁺ can act as MRI contrast agent for tumor diagnosis. Illumination with near-infrared (NIR) light, photothermal conversion effect of GNRs can be activated for synergistic cancer therapy.

Results: In vivo results illustrate that the CM-DOX-GMNPs display tumor specific MRI/PTI ability and excellent inhibition effect on tumor growth.

Conclusion: This bioinspired nanoparticle presents an effective and intelligent approach for tumor imaging and therapy, affording valuable guidance for the rational design of robust theranostics nanoplatform.

Keywords: cancer cell membrane, homotypic targeting, dual-modal imaging, gold nanorod, photothermal therapy.

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APA

Zhang, D., Ye, Z., Liu, H., Wang, X., Hua, J., Ling, Y., Wei, L., Xia, Y., Sun, S., Xiao, L. (2021). Cell membrane coated smart two-dimensional supraparticle for in vivo homotypic cancer targeting and enhanced combinational theranostics. Nanotheranostics, 5(3), 275-287. https://doi.org/10.7150/ntno.57657.

ACS

Zhang, D.; Ye, Z.; Liu, H.; Wang, X.; Hua, J.; Ling, Y.; Wei, L.; Xia, Y.; Sun, S.; Xiao, L. Cell membrane coated smart two-dimensional supraparticle for in vivo homotypic cancer targeting and enhanced combinational theranostics. Nanotheranostics 2021, 5 (3), 275-287. DOI: 10.7150/ntno.57657.

NLM

CSE

Zhang D, Ye Z, Liu H, Wang X, Hua J, Ling Y, Wei L, Xia Y, Sun S, Xiao L. 2021. Cell membrane coated smart two-dimensional supraparticle for in vivo homotypic cancer targeting and enhanced combinational theranostics. Nanotheranostics. 5(3):275-287.

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