Nanotheranostics 2022; 6(1):10-30. doi:10.7150/ntno.61244 This issue Cite

Review

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications

Bohdan Andreiuk1,2✉, Fay Nicolson1,3, Louise M. Clark1,2, Sajanlal R. Panikkanvalappil1, Kenry1,4, Mohammad Rashidian2, Stefan Harmsen5✉, Moritz F. Kircher1,6,†

1. Department of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
2. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
3. Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
4. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
5. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
6. Department of Radiology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 022115, USA.
Deceased August 15, 2020

Citation:
Andreiuk B, Nicolson F, Clark LM, Panikkanvalappil SR, Kenry , Rashidian M, Harmsen S, Kircher MF. Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications. Nanotheranostics 2022; 6(1):10-30. doi:10.7150/ntno.61244. https://www.ntno.org/v06p0010.htm
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Abstract

Graphic abstract

Surface-enhanced Raman spectroscopy (SERS) nanotags hold a unique place among bioimaging contrast agents due to their fingerprint-like spectra, which provide one of the highest degrees of detection specificity. However, in order to achieve a sufficiently high signal intensity, targeting capabilities, and biocompatibility, all components of nanotags must be rationally designed and tailored to a specific application. Design parameters include fine-tuning the properties of the plasmonic core as well as optimizing the choice of Raman reporter molecule, surface coating, and targeting moieties for the intended application. This review introduces readers to the principles of SERS nanotag design and discusses both established and emerging protocols of their synthesis, with a specific focus on the construction of SERS nanotags in the context of bioimaging and theranostics.

Keywords: Surface-enhanced Raman scattering, gold nanostar synthesis, near-infrared dye, cancer imaging


Citation styles

APA
Andreiuk, B., Nicolson, F., Clark, L.M., Panikkanvalappil, S.R., Kenry, , Rashidian, M., Harmsen, S., Kircher, M.F. (2022). Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications. Nanotheranostics, 6(1), 10-30. https://doi.org/10.7150/ntno.61244.

ACS
Andreiuk, B.; Nicolson, F.; Clark, L.M.; Panikkanvalappil, S.R.; Kenry, ; Rashidian, M.; Harmsen, S.; Kircher, M.F. Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications. Nanotheranostics 2022, 6 (1), 10-30. DOI: 10.7150/ntno.61244.

NLM
Andreiuk B, Nicolson F, Clark LM, Panikkanvalappil SR, Kenry , Rashidian M, Harmsen S, Kircher MF. Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications. Nanotheranostics 2022; 6(1):10-30. doi:10.7150/ntno.61244. https://www.ntno.org/v06p0010.htm

CSE
Andreiuk B, Nicolson F, Clark LM, Panikkanvalappil SR, Kenry , Rashidian M, Harmsen S, Kircher MF. 2022. Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications. Nanotheranostics. 6(1):10-30.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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