Nanotheranostics 2022; 6(4):350-364. doi:10.7150/ntno.64790 This issue Cite

Research Paper

A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy

Mehri Mirrahimi1*, Zahra Alamzadeh1*, Jaber Beik1, Abolfazl Sarikhani1, Mahdie Mousavi1, Rasoul Irajirad1, Tahereh Khani1, Elnaz S. Davani1, Ali Farashahi1, Tahereh Shakerian Ardakani2, Jeff W.M. Bulte3,4, Habib Ghaznavi5,✉, Ali Shakeri-Zadeh1,#,✉

1. Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Physics, Payame Noor University, Tehran, Iran
3. The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
4. Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
5. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
# Current address: Russell H. Morgan Department of Radiology, Division of MR Research, 733 N Broadway, MRB 653, Baltimore, MD 21205, USA.
* These authors contributed equally to this work

Citation:
Mirrahimi M, Alamzadeh Z, Beik J, Sarikhani A, Mousavi M, Irajirad R, Khani T, Davani ES, Farashahi A, Ardakani TS, Bulte JWM, Ghaznavi H, Shakeri-Zadeh A. A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy. Nanotheranostics 2022; 6(4):350-364. doi:10.7150/ntno.64790. https://www.ntno.org/v06p0350.htm
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Abstract

Graphic abstract

Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-based smart nanocomposites (NCs), comprising gold nanoparticles (AuNPs) and superparamagnetic iron oxides (SPIOs) scaffolded within graphene oxide (GO) nanosheets, coated with doxorubicin (DOX)-loaded 1-tetradecanol (TD), and further modified with an alginate (Alg) polymer. TD is a phase-change material (PCM) that confines DOX molecules to the GO surface and melts when the temperature exceeds its melting point (Tm=39 °C), causing the PCM to release its drug payload. By virtue of their strong near-infrared (NIR) light absorption and high photothermal conversion efficiency, GO nanosheets may enable photothermal therapy (PTT) and activate a phase change to trigger DOX release. Upon NIR irradiation of NCs, a synergistic thermo-chemotherapeutic effect can be obtained by GO-mediated PTT, resulting an accelerated and controllable drug release through the PCM mechanism. The biodistribution of these NCs could also be imaged with computed tomography (CT) and magnetic resonance (MR) imaging in vitro and in vivo. Hence, this multifunctional nanotheranostic platform based on 2D nanomaterials appears a promising candidate for multimodal image-guided cancer therapy.

Keywords: Graphene oxide, Stimuli-responsive, Phase-change material, Thermo-chemotherapy, Nanotheranostics


Citation styles

APA
Mirrahimi, M., Alamzadeh, Z., Beik, J., Sarikhani, A., Mousavi, M., Irajirad, R., Khani, T., Davani, E.S., Farashahi, A., Ardakani, T.S., Bulte, J.W.M., Ghaznavi, H., Shakeri-Zadeh, A. (2022). A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy. Nanotheranostics, 6(4), 350-364. https://doi.org/10.7150/ntno.64790.

ACS
Mirrahimi, M.; Alamzadeh, Z.; Beik, J.; Sarikhani, A.; Mousavi, M.; Irajirad, R.; Khani, T.; Davani, E.S.; Farashahi, A.; Ardakani, T.S.; Bulte, J.W.M.; Ghaznavi, H.; Shakeri-Zadeh, A. A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy. Nanotheranostics 2022, 6 (4), 350-364. DOI: 10.7150/ntno.64790.

NLM
Mirrahimi M, Alamzadeh Z, Beik J, Sarikhani A, Mousavi M, Irajirad R, Khani T, Davani ES, Farashahi A, Ardakani TS, Bulte JWM, Ghaznavi H, Shakeri-Zadeh A. A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy. Nanotheranostics 2022; 6(4):350-364. doi:10.7150/ntno.64790. https://www.ntno.org/v06p0350.htm

CSE
Mirrahimi M, Alamzadeh Z, Beik J, Sarikhani A, Mousavi M, Irajirad R, Khani T, Davani ES, Farashahi A, Ardakani TS, Bulte JWM, Ghaznavi H, Shakeri-Zadeh A. 2022. A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy. Nanotheranostics. 6(4):350-364.

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