<i>In vivo</i> Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies

Fahmi, Mochamad Zakki; Aung, Yu-Yu; Ahmad, Musbahu Adam; Kristanti, Alfinda Novi; Sakti, Satya Candra Wibawa; Arjasa, Oka Pradipta; Lee, Hwei Voon

doi:10.7150/ntno.80030

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Nanotheranostics 2023; 7(3):281-298. doi:10.7150/ntno.80030 This issue Cite

Research Paper

In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies

Mochamad Zakki Fahmi^1,2,✉, Yu-Yu Aung¹, Musbahu Adam Ahmad¹, Alfinda Novi Kristanti¹, Satya Candra Wibawa Sakti^1,✉, Oka Pradipta Arjasa³, Hwei Voon Lee⁴

1. Department of Chemistry, Airlangga University, Surabaya 60115, Indonesia.
2. Supramodification Nano-micro Engineering (SPANENG) Research Group, Airlangga University, Surabaya 60115, Indonesia.
3. Advanced Materials Research Centre - National Research and Innovation Agency, Central Jakarta 10340, Indonesia.
4. Nanotechnology & Catalysis Research Centre (NANOCAT), Level 3, Block A, Institute for Advanced Studies, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

Citation:

Fahmi MZ, Aung YY, Ahmad MA, Kristanti AN, Sakti SCW, Arjasa OP, Lee HV. In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies. Nanotheranostics 2023; 7(3):281-298. doi:10.7150/ntno.80030. https://www.ntno.org/v07p0281.htm

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Abstract

The fluorescent imaging and drug delivery utilizing carbon dots nanomaterials (CDs) have attracted tremendously due to their unique optical ability and outstanding biocompatibility. Herein, we reported a new design of chalcone-loaded carbon dots (Chalcone-APBA-CDs) to serve chalcone transport onto cancer cells and enhance the CDs bioimaging and antitumor activity. The boronic acid was directly introduced to carbon dots (CDs) via pyrolysis process to drive CDs specifically to the cancer cell, and chalcone was mediated on CDs by ultrasonication to perform facile release of the drug delivery model. The successfully synthesized Chalcone-APBA-CDs were proved by their chemical structure, fluorescent activities, in vitro and in vivo analyses, and drug release systems using different pH. In addition, flow cytometry and confocal fluorescent imaging proved CDs' cellular uptake and imaging performance. In vitro analyses further proved that the Chalcone-APBA-CDs exhibited a higher toxicity value than bare CDs and efficiently inhibited the proliferation of the HeLa cells depending on their dose-response. Finally, the performance of Chalcone-APBA-CDs on cancer healing capability was examined in vivo with fibrosarcoma cancer-bearing mice, which showed a remarkable ability to reduce the tumor volume compared with saline (control). This result strongly suggested that the Chalcone-APBA-CDs appear promising simultaneously as cancer cell imaging and drug delivery.

Keywords: Carbon dots, chalcone, drug release, in vitro and in vivo assay

Citation styles

APA

Fahmi, M.Z., Aung, Y.Y., Ahmad, M.A., Kristanti, A.N., Sakti, S.C.W., Arjasa, O.P., Lee, H.V. (2023). In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies. Nanotheranostics, 7(3), 281-298. https://doi.org/10.7150/ntno.80030.

ACS

Fahmi, M.Z.; Aung, Y.Y.; Ahmad, M.A.; Kristanti, A.N.; Sakti, S.C.W.; Arjasa, O.P.; Lee, H.V. In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies. Nanotheranostics 2023, 7 (3), 281-298. DOI: 10.7150/ntno.80030.

NLM

CSE

Fahmi MZ, Aung YY, Ahmad MA, Kristanti AN, Sakti SCW, Arjasa OP, Lee HV. 2023. In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies. Nanotheranostics. 7(3):281-298.

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